A world-wide group of scientists have confirmed 5 variants of genes that are directly linked with Parkinson’s Disease, concluding the tally up to 11, as per accordance to a news paper that was published this Wednesday from the Lancet.
Since the first discovery of genetic clue in 1997, the consensus from medical organizations observed that Parkinson’s Disease has actually non-inherited, that is to say environmental causes.
These 5 variants were discovered in a research overview of a genomic studies tht was carried out by the scientists fro great Britain, France, Netherlands, Germany, United States, and Iceland.
Parkinson’s Disease was first described as Shaking Palsy, and it was named Parkinson’s Disease after the essay reports given by James Parkinson in 1817 which described that characteristics of the disease, and hence it was named after him as Parkinson’s Disease.
Parkinson’s disease is well understood compared to other neurological disorders, because symptoms of Parkinson’s disease are proven to be caused by loss of some particular group of cells in a particular part of the human brain. However, What is still not known, is the reasoning behind the cause of those particular cells to be lost.
The 20 percent of patients who had the highest number of variants were two and a half times likelier to develop Parkinson’s compared to the 20 percent with the least variants, the researchers found.
If patient doesn’t get treatment in time, the symptoms of Parkinson’s Disease can worsen in a quick span of time, but once it has worsen then its progression will slow down. However its un-common to find such a patient nowadays that is still untreated for his Parkinson’s Disease, but some medication used for this disease causes side-effects and/or only slow down the progression of disease, making this disease incurable.
Parkinson’s Disease essentially impairs the patient’s movement abilities, hence producing progressive motor symptoms. And it also produces some non-motor symptoms that are mainly consisting of autonomic dysfunction, neuropsychiatric problems, sensory disabilities, behavioral and cognitive issues, and sleep disturbance.
Parkinson’s Disease can easily cause sleep disturbance by manifesting itself as daytime sleepiness, impaired REM session, and as insomnia. Profuse sweating and sexual dysfunctions are also one of the cl(–foul word(s) removed–)ic symptoms of Parkinson’s Disease.
Constipation of the patient can become severe enough to become not only a discomfort but also lethal for one’s health. Sensory dysfunction include impairment of sense of smell, paresthasia, and sense of perceiving pain.
Parkinson Disease itself is not fatal but an untreated Parkinson’s Disease can lead to a severely disabling quality of life, and complications of this disease may cause death (i.e. progressive disability of upper and lower GI tract)
